ASML Holding vs AstraZeneca: Founders, CEOs and History

Company facts

Founders

CEOs and their tenures

Timeline: ASML Holding and AstraZeneca side by side

1. 1913AstraZeneca

   Astra AB Founded in Södertälje, Sweden

   400 doctors and apothecaries establish Astra AB to manufacture pharmaceuticals for the Swedish market, creating the foundation for what would become one of Europe's largest drug companies.

2. 1984ASML Holding

   Founded as ASM Lithography in Eindhoven

   ASM Lithography starts operations on April 1, 1984 as a joint venture between Philips and ASM International, with the mandate to commercialize the PAS 2000 wafer stepper developed inside Philips.

3. 1986ASML Holding

   PAS 2500 stepper and the Carl Zeiss partnership

   ASML brings the PAS 2500 stepper to market with a new wafer alignment system developed by first chief scientist Steef Wittekoek, and establishes the optics partnership with Carl Zeiss that still supplies every ASML lithography system.

4. 1988ASML Holding

   ASM International withdraws and Philips funds a rescue

   With few customers and heavy cash consumption, ASM International decides to stop funding the joint venture while Philips launches a company-wide cost-cutting program.

5. 1991ASML Holding

   PAS 5500 platform turns the company around

   ASML launches the PAS 5500 platform, whose productivity and resolution win the first large orders from Intel and IBM under chief executive Willem Maris and take the company to profitability. PAS 5500 systems are still running in customer fabs decades later.

6. 1993AstraZeneca

   Zeneca Group Spun Off from ICI

   Imperial Chemical Industries demerges its pharmaceuticals and agrochemicals businesses to form Zeneca Group PLC, with initial products including Zestril, Nolvadex, and Zoladex generating approximately $3.2 billion in annual sales.

7. 1995ASML Holding

   IPO in Amsterdam and on Nasdaq

   ASML becomes a fully independent public company with a dual listing on the Amsterdam Stock Exchange and Nasdaq. Philips sells half of its shares at the IPO and divests the remainder over the following years.

8. 1999AstraZeneca

   Astra and Zeneca Merge to Form AstraZeneca

   The all-share merger of equals completes on 6 April 1999, creating AstraZeneca PLC.

9. 2000AstraZeneca

   Nexium Launch Replaces Prilosec

   AstraZeneca launches Nexium (esomeprazole), the single-isomer successor to Losec/Prilosec, in Europe in 2000 and in the United States in 2001 after FDA approval on 20 February 2001.

10. 2001ASML Holding

    TWINSCAN platform launched and Silicon Valley Group acquired

    ASML introduces the TWINSCAN dual-stage architecture, which exposes one wafer while the next is measured and aligned, lifting throughput and overlay accuracy above competing systems.

11. 2003ASML Holding

    First immersion lithography system

    The TWINSCAN AT:1150i debuts as ASML's first immersion machine, projecting 193 nanometer light through a layer of ultrapure water between the lens and the wafer to raise resolution.

12. 2006AstraZeneca

    Acquisition of Cambridge Antibody Technology

    AstraZeneca agrees in May 2006 to buy Cambridge Antibody Technology for 1,320 pence a share, valuing the UK biotech at 702 million pounds or about $1.32 billion.

13. 2007AstraZeneca

    Acquisition of MedImmune for $15.6 Billion

    AstraZeneca acquires MedImmune for $15.6 billion, entering the biologics market and gaining the Synagis respiratory syncytial virus franchise and antibody technology platforms. The Gaithersburg facility becomes one of three global R&D centres.

14. 2010ASML Holding

    First EUV prototype shipped

    ASML ships the TWINSCAN NXE:3100, its first extreme ultraviolet lithography tool, to the research facility of an Asian chipmaker.

15. 2012ASML Holding

    Customer Co-Investment Program with Intel, TSMC and Samsung

    Intel, TSMC and Samsung acquire newly issued ASML shares equal to an aggregate 23 percent minority stake for ~$4.35 billion (3.85 billion euros) in cash, and separately commit ~$1.56 billion (1.38 billion euros) of R&D funding over five years dedicated to EUV…

16. 2012AstraZeneca

    Pascal Soriot Appointed CEO

    Pascal Soriot joins AstraZeneca as Chief Executive Officer on October 1, 2012, with a base salary of $1.4 million and a mandate to reverse declining revenue and R&D productivity through science-led investment.

17. 2013ASML Holding

    Cymer acquisition completed and second-generation EUV shipped

    ASML completes the acquisition of Cymer, the San Diego supplier of the light sources used in its lithography systems, in a cash-and-stock deal valued at ~$2.2 billion (1.95 billion euros) when it was agreed in October 2012.

18. 2014AstraZeneca

    Pfizer Hostile Takeover Rejected

    AstraZeneca's board rejects a $117 billion hostile takeover offer from Pfizer, with Soriot arguing that the undervaluation would destroy long-term shareholder value and pipeline potential.

19. 2014AstraZeneca

    Acquisition of Almirall Respiratory Portfolio

    AstraZeneca acquires the respiratory portfolio of Spanish pharmaceutical company Almirall for approximately $2.1 billion, strengthening the company's position in COPD and asthma with products including Eklira and pipeline candidates that become Breztri.

20. 2015AstraZeneca

    Tagrisso Approved for EGFR-Mutated Lung Cancer

    The FDA approves Tagrisso (osimertinib) in November 2015 for metastatic EGFR T790M mutation-positive non-small cell lung cancer, the first product from Soriot's reinvestment strategy to reach market.

21. 2017ASML Holding

    EUV enters high-volume manufacturing

    ASML begins shipping the production-ready TWINSCAN NXE:3400B after customers started ordering the NXE:3400 generation in batches in 2016, roughly two decades after EUV research began.

22. 2017AstraZeneca

    Imfinzi Approved Based on PACIFIC Trial

    The FDA approves Imfinzi (durvalumab) for unresectable stage III non-small cell lung cancer after chemoradiation, based on PACIFIC trial data showing survival benefits.

23. 2019ASML Holding

    Dutch government stops EUV exports to China

    The Netherlands does not renew ASML's export licence for EUV systems to China, the start of a widening export control regime.

24. 2020AstraZeneca

    COVID-19 Vaccine Development with Oxford University

    AstraZeneca partners with the University of Oxford to develop and manufacture the Vaxzevria COVID-19 vaccine, distributing billions of doses globally at nonprofit pricing during the pandemic peak.

25. 2021AstraZeneca

    Acquisition of Alexion Pharmaceuticals for $39 Billion

    AstraZeneca completes the $39 billion acquisition of Alexion on July 21, 2021, entering the rare disease market with Soliris and Ultomiris and creating a dedicated rare disease unit headquartered in Boston.

26. 2023ASML Holding

    First High-NA EUV system shipped

    ASML ships the first of its next-generation EUV systems with a numerical aperture of 0.55, the TWINSCAN EXE:5000, to Intel in Hillsboro, Oregon.

27. 2023AstraZeneca

    CinCor Pharma Acquired for up to $1.8 Billion

    AstraZeneca agrees on 9 January 2023 to acquire CinCor Pharma for up to $1.8 billion, $26 per share in cash plus a $10 per share contingent value right, to gain baxdrostat, an aldosterone synthase inhibitor for resistant hypertension.

28. 2024ASML Holding

    Christophe Fouquet becomes chief executive

    Peter Wennink and Martin van den Brink step down as presidents of ASML on April 24, 2024 and Christophe Fouquet becomes president, chief executive officer and chair of the Board of Management.

29. 2024AstraZeneca

    Total Revenue Reaches $54.073 Billion

    AstraZeneca reports Total Revenue of $54.073 billion for fiscal year 2024, an 18% increase at actual rates and 21% at constant exchange rates, with 16 blockbuster medicines, 74 regulatory events, and 24 pipeline progression events.

30. 2024AstraZeneca

    Fusion Pharmaceuticals and Gracell Acquisitions

    AstraZeneca acquires Fusion Pharmaceuticals for $2 billion to access radiopharmaceutical technology and Gracell Biotechnologies for $1.2 billion for cell therapy manufacturing, expanding modality diversity into radiopharmaceuticals and CAR-T.

31. 2025ASML Holding

    Record year, first EXE:5200B and Mistral AI investment

    ASML reports total net sales of ~$37 billion (32.7 billion euros), up 15.6 percent, net income of ~$10.8 billion (9.6 billion euros), a gross margin of 52.8 percent and 535 systems sold, and closes the year with a backlog of ~$43.8 billion (38.8 billion euros)…

32. 2025AstraZeneca

    Total Revenue Reaches $58.739 Billion

    AstraZeneca reports Total Revenue of $58.739 billion for fiscal year 2025, an 8% increase at constant exchange rates, with 16 positive Phase III readouts, 43 major market approvals, and a commitment to invest $50 billion in U.S. manufacturing by 2030.

33. 2025AstraZeneca

    EsoBiotec Acquired for Up to $1 Billion

    AstraZeneca acquires Belgian biotech EsoBiotec for up to $1 billion to access in vivo cell therapy technology, eliminating the need for ex vivo manufacturing in CAR-T therapies.

34. 2025AstraZeneca

    $50 Billion US Manufacturing and R&D Commitment

    AstraZeneca announces on 21 July 2025 that it will invest $50 billion in United States manufacturing and research by 2030, including a new Virginia facility later raised to $4.5 billion.

35. 2026AstraZeneca

    Ordinary Shares Begin Trading on the NYSE

    AstraZeneca ordinary shares start trading on the New York Stock Exchange on 2 February 2026 under the ticker AZN, after the American Depositary Share programme and certain debt securities stopped trading on Nasdaq on 30 January 2026.

36. 2026AstraZeneca

    Baxfendy Approved in the US for Hypertension

    The FDA approves Baxfendy (baxdrostat) in May 2026 as the first aldosterone synthase inhibitor for hypertension, used in combination with other antihypertensives in adults who are not adequately controlled.

37. 2026AstraZeneca

    $15 Billion China Investment Through 2030

    AstraZeneca announces on 29 January 2026 that it will invest $15 billion in China through 2030 to expand manufacturing and research, in a market that is its second largest and about 12% of revenue.

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