Modern Sanofi took shape in 2004 when Sanofi-Synthélabo won a hostile takeover of the larger Franco-German group Aventis, with the French government favoring a domestic deal over a rival approach from Novartis.
The Lantus Patent Cliff
For years Sanofi relied on Lantus, its long-acting insulin. US exclusivity ended in 2015, competing insulins such as Eli Lilly's Basaglar arrived, and diabetes sales declined, prompting a search for new growth.
Play to Win
Paul Hudson became CEO in 2019 and launched 'Play to Win', stopping most diabetes and cardiovascular research and focusing on immunology, vaccines and rare diseases.
Dupixent
Dupixent, developed with Regeneron and first approved in 2017, grew into Sanofi's largest product, with ~$17.7 billion (EUR15.7 billion) of sales in 2025 and more than $5.65 billion (EUR5 billion) in Q2 2026 alone.
Opella and the 2026 Leadership Change
In April 2025 Sanofi sold a 50% controlling stake in its consumer health unit Opella to CD&R, keeping 48.2%. In February 2026 the board declined to renew Hudson's mandate, and former Merck KGaA CEO Belén Garijo took over after the April 29, 2026 AGM.