AstraZeneca vs Novo Nordisk: Founders, CEOs and History

Company facts

Founders

CEOs and their tenures

Timeline: AstraZeneca and Novo Nordisk side by side

1. 1913AstraZeneca

   Astra AB Founded in Södertälje, Sweden

   400 doctors and apothecaries establish Astra AB to manufacture pharmaceuticals for the Swedish market, creating the foundation for what would become one of Europe's largest drug companies.

2. 1923Novo Nordisk

   Founding of Nordisk Insulinlaboratorium

   August Krogh and Hans Christian Hagedorn founded the Nordisk Insulinlaboratorium in Copenhagen, securing the licensing rights to produce insulin for the Scandinavian countries.

3. 1925Novo Nordisk

   Founding of Novo Terapeutisk Laboratorium

   Harald Pedersen and a group of Danish physicians founded Novo Terapeutisk Laboratorium to produce insulin and other biological products using industrial-scale fermentation processes.

4. 1989Novo Nordisk

   Merger of Novo and Nordisk

   The $1.5 billion merger of Novo Industri and Nordisk Insulinlaboratorium was completed, creating Novo Nordisk A/S as one of the world's largest insulin manufacturers.

5. 1993AstraZeneca

   Zeneca Group Spun Off from ICI

   Imperial Chemical Industries demerges its pharmaceuticals and agrochemicals businesses to form Zeneca Group PLC, with initial products including Zestril, Nolvadex, and Zoladex generating approximately $3.2 billion in annual sales.

6. 1999AstraZeneca

   Astra and Zeneca Merge to Form AstraZeneca

   The all-share merger of equals completes on 6 April 1999, creating AstraZeneca PLC.

7. 2000AstraZeneca

   Nexium Launch Replaces Prilosec

   AstraZeneca launches Nexium (esomeprazole), the single-isomer successor to Losec/Prilosec, in Europe in 2000 and in the United States in 2001 after FDA approval on 20 February 2001.

8. 2005Novo Nordisk

   Launch of Insulin detemir (Levemir)

   Novo Nordisk launched Insulin detemir, a long-acting basal insulin analog with a flat action profile and reduced risk of hypoglycemia compared to NPH insulin.

9. 2006AstraZeneca

   Acquisition of Cambridge Antibody Technology

   AstraZeneca agrees in May 2006 to buy Cambridge Antibody Technology for 1,320 pence a share, valuing the UK biotech at 702 million pounds or about $1.32 billion.

10. 2007AstraZeneca

    Acquisition of MedImmune for $15.6 Billion

    AstraZeneca acquires MedImmune for $15.6 billion, entering the biologics market and gaining the Synagis respiratory syncytial virus franchise and antibody technology platforms. The Gaithersburg facility becomes one of three global R&D centres.

11. 2009Novo Nordisk

    Launch of Victoza (liraglutide)

    Novo Nordisk launched Victoza, the first once-daily GLP-1 receptor agonist, marking the company's strategic pivot from insulin to incretin-based therapies.

12. 2012AstraZeneca

    Pascal Soriot Appointed CEO

    Pascal Soriot joins AstraZeneca as Chief Executive Officer on October 1, 2012, with a base salary of $1.4 million and a mandate to reverse declining revenue and R&D productivity through science-led investment.

13. 2014AstraZeneca

    Pfizer Hostile Takeover Rejected

    AstraZeneca's board rejects a $117 billion hostile takeover offer from Pfizer, with Soriot arguing that the undervaluation would destroy long-term shareholder value and pipeline potential.

14. 2014AstraZeneca

    Acquisition of Almirall Respiratory Portfolio

    AstraZeneca acquires the respiratory portfolio of Spanish pharmaceutical company Almirall for approximately $2.1 billion, strengthening the company's position in COPD and asthma with products including Eklira and pipeline candidates that become Breztri.

15. 2015AstraZeneca

    Tagrisso Approved for EGFR-Mutated Lung Cancer

    The FDA approves Tagrisso (osimertinib) in November 2015 for metastatic EGFR T790M mutation-positive non-small cell lung cancer, the first product from Soriot's reinvestment strategy to reach market.

16. 2017AstraZeneca

    Imfinzi Approved Based on PACIFIC Trial

    The FDA approves Imfinzi (durvalumab) for unresectable stage III non-small cell lung cancer after chemoradiation, based on PACIFIC trial data showing survival benefits.

17. 2017Novo Nordisk

    Launch of Ozempic (semaglutide)

    Novo Nordisk launched Ozempic, a once-weekly GLP-1 receptor agonist for type 2 diabetes, which became the fastest-growing diabetes drug in history.

18. 2020AstraZeneca

    COVID-19 Vaccine Development with Oxford University

    AstraZeneca partners with the University of Oxford to develop and manufacture the Vaxzevria COVID-19 vaccine, distributing billions of doses globally at nonprofit pricing during the pandemic peak.

19. 2021AstraZeneca

    Acquisition of Alexion Pharmaceuticals for $39 Billion

    AstraZeneca completes the $39 billion acquisition of Alexion on July 21, 2021, entering the rare disease market with Soliris and Ultomiris and creating a dedicated rare disease unit headquartered in Boston.

20. 2021Novo Nordisk

    Launch of Wegovy (semaglutide 2.4mg)

    Novo Nordisk launched Wegovy, a high-dose formulation of semaglutide for chronic weight management, demonstrating an average weight loss of 14.9% in the STEP-1 trial.

21. 2023AstraZeneca

    CinCor Pharma Acquired for up to $1.8 Billion

    AstraZeneca agrees on 9 January 2023 to acquire CinCor Pharma for up to $1.8 billion, $26 per share in cash plus a $10 per share contingent value right, to gain baxdrostat, an aldosterone synthase inhibitor for resistant hypertension.

22. 2023Novo Nordisk

    SELECT Trial Results

    Novo Nordisk announced the results of the SELECT trial, demonstrating a 20% reduction in major adverse cardiovascular events for semaglutide 2.4mg in non-diabetic obese patients.

23. 2024AstraZeneca

    Total Revenue Reaches $54.073 Billion

    AstraZeneca reports Total Revenue of $54.073 billion for fiscal year 2024, an 18% increase at actual rates and 21% at constant exchange rates, with 16 blockbuster medicines, 74 regulatory events, and 24 pipeline progression events.

24. 2024AstraZeneca

    Fusion Pharmaceuticals and Gracell Acquisitions

    AstraZeneca acquires Fusion Pharmaceuticals for $2 billion to access radiopharmaceutical technology and Gracell Biotechnologies for $1.2 billion for cell therapy manufacturing, expanding modality diversity into radiopharmaceuticals and CAR-T.

25. 2024Novo Nordisk

    Catalent Acquisition

    Novo Holdings completed its $16.5 billion acquisition of Catalent in December 2024, and Novo Nordisk bought three Catalent fill-finish sites in Italy, Belgium and Indiana for $11 billion to expand Wegovy and Ozempic capacity.

26. 2024Novo Nordisk

    FY2024 Financial Results

    Novo Nordisk reported FY2024 net sales of ~$44.1 billion (DKK 290.4 billion), up 25% in DKK, and net profit of ~$15.4 billion (DKK 101.0 billion).

27. 2025AstraZeneca

    Total Revenue Reaches $58.739 Billion

    AstraZeneca reports Total Revenue of $58.739 billion for fiscal year 2025, an 8% increase at constant exchange rates, with 16 positive Phase III readouts, 43 major market approvals, and a commitment to invest $50 billion in U.S. manufacturing by 2030.

28. 2025AstraZeneca

    EsoBiotec Acquired for Up to $1 Billion

    AstraZeneca acquires Belgian biotech EsoBiotec for up to $1 billion to access in vivo cell therapy technology, eliminating the need for ex vivo manufacturing in CAR-T therapies.

29. 2025AstraZeneca

    $50 Billion US Manufacturing and R&D Commitment

    AstraZeneca announces on 21 July 2025 that it will invest $50 billion in United States manufacturing and research by 2030, including a new Virginia facility later raised to $4.5 billion.

30. 2025Novo Nordisk

    CEO Change and Restructuring

    Mike Doustdar replaced Lars Fruergaard Jørgensen as CEO on August 7, 2025, and in September the company announced about 9,000 job cuts. Lars Rebien Sørensen later became board chair after a dispute with the Novo Nordisk Foundation over board composition.

31. 2026AstraZeneca

    Ordinary Shares Begin Trading on the NYSE

    AstraZeneca ordinary shares start trading on the New York Stock Exchange on 2 February 2026 under the ticker AZN, after the American Depositary Share programme and certain debt securities stopped trading on Nasdaq on 30 January 2026.

32. 2026AstraZeneca

    Baxfendy Approved in the US for Hypertension

    The FDA approves Baxfendy (baxdrostat) in May 2026 as the first aldosterone synthase inhibitor for hypertension, used in combination with other antihypertensives in adults who are not adequately controlled.

33. 2026AstraZeneca

    $15 Billion China Investment Through 2030

    AstraZeneca announces on 29 January 2026 that it will invest $15 billion in China through 2030 to expand manufacturing and research, in a market that is its second largest and about 12% of revenue.

34. 2026Novo Nordisk

    Wegovy Pill Launch

    After FDA approval in December 2025, Novo launched the oral Wegovy pill in the US in January 2026; it passed 5 million prescriptions by August 2026 and received EU approval in July 2026.

35. 2026Novo Nordisk

    Capital Markets Day

    On September 21, 2026 Novo set 2030 targets of mid-single-digit sales growth and more than five multi-blockbuster launches; the shares fell about 8%.

Acquisitions

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