American Express vs Pfizer: Founders, CEOs and History
American Express was founded in 1850 by Henry Wells, William Fargo, John Warren Butterfield and is led by Stephen Squeri. Pfizer was founded in 1849 by Charles Pfizer, Charles Erhart and is led by Albert Bourla.
Company facts
American Express
- Founded
- 1850
- Headquarters
- New York, New York
- Current CEO
- Stephen Squeri
- Employees
- 76,800
Pfizer
- Founded
- 1849
- Headquarters
- New York, New York
- Current CEO
- Albert Bourla
- Employees
- 75,000
Founders
American Express
Henry Wells
The founding of American Express is a fascinating story of intense 19th-century corporate rivalry culminating in a monopolistic merger.
William Fargo
William Fargo co-founded American Express in 1850 alongside Henry Wells and John Butterfield, bringing operational discipline and route management expertise to the merger of competing express businesses.
John Warren Butterfield
John Warren Butterfield was one of the three founders of American Express in 1850 and served as a director, bringing the organizational resources, political connections and financial backing that made the merger viable.
Pfizer
Charles Pfizer
Pfizer possesses a historic, immigrant founding story, rooted entirely in the rapid industrial expansion of 19th-century Brooklyn and defined by an effective, intensely meticulous German chemist and his ambitious confectioner cousin.
Charles Erhart
Charles Erhart's role in Pfizer's founding is less celebrated than his cousin's, partly because the company carries Charles Pfizer's name and partly because his commercial contributions were less visible than the scientific achievements that drove the company'…
CEOs and their tenures
American Express
- Howard L. Clark Sr.1960–1977
President and Chief Executive Officer
Howard Clark became chief executive in 1960 and ran American Express until 1977. He inherited a charge card business that was losing money two years after launch and pushed it to profitability by repositioning it as a premium product, raising the merchant disc…
Source - James D. Robinson III1977–1993
Chairman and Chief Executive Officer
James Robinson III presided over American Express during a period of both genuine growth and serious strategic overreach.
Source - Harvey Golub1993–2001
Chairman and Chief Executive Officer
Harvey Golub inherited a company left unfocused and financially weaker by James Robinson III's financial conglomerate strategy.
Source - Kenneth Chenault2001–2018
Chairman and Chief Executive Officer
Kenneth Chenault led American Express for 17 years through two severe shocks: the September 11 attacks in 2001, which hit its lower Manhattan operations and its travel-dependent business weeks after he became chief executive, and the 2008 financial crisis, dur…
Source - Stephen J. Squeri2018–present
Chairman and Chief Executive Officer
Stephen Squeri took over from Kenneth Chenault in February 2018 and has run the most financially productive period in the company's history, with FY2025 total revenues net of interest expense of $72.2 billion and net income of $10.8 billion, both records.
Source
Pfizer
- Ian Read2010–2018
Chief Executive Officer
He ruthlessly cut R&D spending and eliminated tens of thousands of jobs, significantly boosting short-term earnings per share despite massive patent cliffs for blockbuster drugs like Lipitor.
Source - Albert Bourla2019–present
Chairman and Chief Executive Officer
A veterinarian by training who joined Pfizer Animal Health in 1993, Bourla became CEO on January 1, 2019 and Chairman in 2020.
Source - Dave Denton2022–2026
Chief Financial Officer
As CFO, he aggressively restructured the balance sheet following the Seagen acquisition, prioritizing debt reduction while defending the dividend.
Source - Chris Boshoff2025–present
Chief Scientific Officer and President, Research & Development
He completely restructured the research and development organization to focus on antibody-drug conjugates (ADCs), aggressively expanding Pfizer's pipeline of cancer therapeutics.
Source - Cecile Guegan2026–present
Interim Chief Financial Officer
She modernized the company's internal auditing and compliance structures, ensuring rapid but safe clinical execution for high-priority vaccine programs.
Source
Timeline: American Express and Pfizer side by side
1849Pfizer
Pfizer Founded
Charles Pfizer and Charles Erhart founded the company in Brooklyn.
1850American Express
American Express founded in Buffalo, New York
Henry Wells, William Fargo and John Butterfield merged three competing express businesses on March 18, 1850 to form the American Express Company, an unincorporated joint-stock association capitalized at 150,000 dollars.
1882American Express
Money order launched
American Express introduced its own money order, competing directly with the postal money order the United States Post Office had offered since 1864.
1891American Express
Traveler's cheque invented
Marcellus Berry created the American Express Traveler's Cheque after president J.C. Fargo struggled to cash letters of credit on a European trip in 1890.
1917American Express
Federal control of the express industry
Federal control of the railroads began in December 1917, and in 1918 the domestic express operations of American Express and its rivals were consolidated into the American Railway Express Company.
1944Pfizer
Penicillin Scale-Up
Pfizer helped industrialize penicillin production during World War II.
1958American Express
First American Express charge card
American Express issued its first charge card on October 1, 1958, printed on paper with a 6 dollar annual fee, after signing up more than 250,000 card members before launch.
1966American Express
Gold Card introduced
American Express launched the Gold Card in 1966 for higher-spending executives and frequent travelers, the first tier above the standard card and the start of the graded premium lineup that later added the Platinum Card and the Centurion Card.
1984American Express
Platinum Card launched during the financial supermarket build-out
American Express introduced The Platinum Card by invitation in 1984 with a 250 dollar annual fee, creating the ultra-premium card category.
1993American Express
Harvey Golub refocuses the company
Harvey Golub became chief executive in 1993 and unwound the conglomerate: the Shearson brokerage went to Primerica's Smith Barney and The Boston Company to Mellon Bank in 1993, and Lehman Brothers was spun off in 1994.
1998Pfizer
Viagra Approved
The FDA approved Viagra in 1998.
1999American Express
Centurion Card launched
American Express created the Centurion Card in 1999, an invitation-only metal card that became the top tier of its lineup. The company has never published its fee schedule, and the product functions mainly as a positioning device for the cards below it.
2000Pfizer
Warner-Lambert Deal
Pfizer acquired Warner-Lambert, adding Lipitor.
2001American Express
Kenneth Chenault becomes chief executive
Kenneth Chenault became chief executive in January 2001, weeks before the September 11 attacks damaged the company's lower Manhattan operations and cut travel spending sharply.
2008American Express
Conversion to a bank holding company
On November 10, 2008 the Federal Reserve Board approved applications by American Express Company and American Express Travel Related Services to become bank holding companies, on conversion of American Express Centurion Bank from an industrial loan company int…
2016American Express
Costco co-brand ends
Costco moved its United States co-branded card to Citigroup and Visa on June 20, 2016, ending a 16-year exclusive relationship after the two sides failed to agree terms, and stopped accepting American Express cards in its warehouses.
2018American Express
Stephen Squeri becomes chairman and chief executive
Stephen Squeri succeeded Kenneth Chenault in February 2018 after more than three decades inside the company, including spells as chief information officer and group president of Global Corporate Services.
2019Pfizer
Albert Bourla becomes CEO
Albert Bourla became CEO of Pfizer in 2019. A veterinarian by training who joined Pfizer Animal Health in 1993, Bourla became CEO on January 1, 2019 and Chairman in 2020.
2020American Express
Pandemic hits travel and entertainment spending
COVID-19 restrictions cut the travel and entertainment spending American Express depends on, and total revenues net of interest expense fell from 43.6 billion dollars in 2019 to 36.1 billion dollars in 2020, with net income down to 3.1 billion dollars.
2020Pfizer
BioNTech COVID Vaccine Partnership
Pfizer and BioNTech brought Comirnaty through emergency authorization.
2023Pfizer
Seagen Acquisition
Pfizer completed the $43 billion Seagen acquisition.
2024American Express
Tock acquisition widens the dining platform
American Express agreed in June 2024 to buy Tock, a reservation, table and event management platform, from Squarespace for 400 million dollars in cash, pairing it with Resy, which it had bought in 2019.
2025American Express
Platinum refresh and record FY2025 results
American Express unveiled refreshed United States Consumer and Business Platinum Cards on September 18, 2025, raising the annual fee from 695 dollars to 895 dollars and adding statement credits it values at over 3,500 dollars a year.
2025Pfizer
Chris Boshoff Becomes CSO
Chris Boshoff became Chief Scientific Officer and President, Research & Development effective January 1, 2025.
2025Pfizer
Metsera Acquisition
Pfizer completed its acquisition of obesity drug developer Metsera in November 2025 for up to about $10 billion including CVRs.
2025Pfizer
FY2025 Revenue Base
Pfizer reported $62.579 billion of FY2025 revenue.
2026Pfizer
Innovent Oncology Collaboration
Pfizer signed a 12-program cancer collaboration with Innovent Biologics: $650 million upfront and up to $9.85 billion in milestones.
Acquisitions
American Express
- Center2025Undisclosed
- Tock2024$400M
- Kabbage2020Undisclosed
- Resy2019Undisclosed
- Loyalty Partner2011$660M
- Thomas Cook corporate travel and United States travel offices1994$375M
Pfizer
- Metsera, Inc.2025$7B
- Seagen Inc.2023$43B
- Medivation Inc.2016$14B
- Wyeth2009$68B
- Pharmacia Corporation2003$60B
- Warner-Lambert Company2000$111B
Questions about American Express vs Pfizer
Who is the CEO of American Express Company and Pfizer Inc.?
American Express Company is led by Stephen Squeri and Pfizer Inc. is led by Albert Bourla. Both serve as the top executive responsible for the company's strategy, operations, and financial performance.
When was American Express Company founded vs Pfizer Inc.?
Pfizer Inc. was founded in 1849 — 1 year before American Express Company, which was founded in 1850. Pfizer Inc.'s longer operating history gives it a deeper track record but also potentially more institutional inertia compared to the younger American Express Company.
How many employees does American Express Company have compared to Pfizer Inc.?
American Express Company employs approximately 76,800 people, while Pfizer Inc. employs approximately 75,000. American Express Company has the larger workforce at 76,800 employees, compared to Pfizer Inc.'s 75,000. A higher headcount does not necessarily imply greater efficiency — it often reflects differences in business model (e.g., manufacturing vs. software).
Where are American Express Company and Pfizer Inc. headquartered?
Both American Express Company and Pfizer Inc. are headquartered in United States, meaning they operate under the same primary regulatory and tax environment.
Who founded American Express Company and Pfizer Inc.?
American Express Company was founded by Henry Wells, William Fargo, John Warren Butterfield. Pfizer Inc. was founded by Charles Pfizer, Charles Erhart.
Which company has a longer operating history — American Express Company or Pfizer Inc.?
Pfizer Inc. has been operating for approximately 177 years, making it the more established of the two companies. American Express Company has been in operation for around 176 years. A longer operating history often signals greater institutional resilience and brand recognition, though it can also mean slower adaptation to new market conditions.
Figures come from each company's filings and the sources linked beside them. Amounts reported in another currency are shown in US dollars at an approximate rate and marked with ~. Back to the American Express vs Pfizer overview