American Express vs Amgen: Founders, CEOs and History

Company facts

Founders

CEOs and their tenures

Timeline: American Express and Amgen side by side

1. 1850American Express

   American Express founded in Buffalo, New York

   Henry Wells, William Fargo and John Butterfield merged three competing express businesses on March 18, 1850 to form the American Express Company, an unincorporated joint-stock association capitalized at 150,000 dollars.

2. 1882American Express

   Money order launched

   American Express introduced its own money order, competing directly with the postal money order the United States Post Office had offered since 1864.

3. 1891American Express

   Traveler's cheque invented

   Marcellus Berry created the American Express Traveler's Cheque after president J.C. Fargo struggled to cash letters of credit on a European trip in 1890.

4. 1917American Express

   Federal control of the express industry

   Federal control of the railroads began in December 1917, and in 1918 the domestic express operations of American Express and its rivals were consolidated into the American Railway Express Company.

5. 1958American Express

   First American Express charge card

   American Express issued its first charge card on October 1, 1958, printed on paper with a 6 dollar annual fee, after signing up more than 250,000 card members before launch.

6. 1966American Express

   Gold Card introduced

   American Express launched the Gold Card in 1966 for higher-spending executives and frequent travelers, the first tier above the standard card and the start of the graded premium lineup that later added the Platinum Card and the Centurion Card.

7. 1980Amgen

   Applied Molecular Genetics is incorporated

   Applied Molecular Genetics (AMGen) was incorporated on April 8, 1980 in Thousand Oaks, California, as the idea of venture capitalist William K. Bowes Jr. and a group of scientific collaborators.

8. 1983Amgen

   Nasdaq listing and the erythropoietin clone

   Amgen completed its initial public offering on June 17, 1983, raising nearly US$40 million under chief financial officer Gordon Binder, and formally shortened its name to Amgen.

9. 1984American Express

   Platinum Card launched during the financial supermarket build-out

   American Express introduced The Platinum Card by invitation in 1984 with a 250 dollar annual fee, creating the ultra-premium card category.

10. 1984Amgen

    Kirin-Amgen joint venture formed

    Amgen and Kirin Brewery Company of Japan formed Kirin-Amgen in 1984 as a joint venture for the worldwide commercialization of erythropoietin.

11. 1985Amgen

    G-CSF cloned, leading to Neupogen

    While Fu-Kuen Lin's team worked on erythropoietin, researcher Larry Souza and his group cloned and expressed human granulocyte colony-stimulating factor in 1985.

12. 1989Amgen

    FDA approves Epogen

    The FDA approved Epogen (epoetin alfa) on June 1, 1989 for anemia in patients with chronic kidney failure on dialysis. It was the first commercial recombinant human erythropoietin. Epogen's U.S.

13. 1991Amgen

    Neupogen approved, giving Amgen a second franchise

    The FDA approved Neupogen (filgrastim) in February 1991. By stimulating white blood cell production it reduced the risk of infection in cancer patients with chemotherapy-induced neutropenia.

14. 1991Amgen

    Amgen wins the erythropoietin patent fight

    On March 6, 1991 the U.S. Court of Appeals for the Federal Circuit upheld the Kirin-Amgen erythropoietin patent and ruled against Genetics Institute in Amgen v. Chugai Pharmaceutical and Genetics Institute.

15. 1993American Express

    Harvey Golub refocuses the company

    Harvey Golub became chief executive in 1993 and unwound the conglomerate: the Shearson brokerage went to Primerica's Smith Barney and The Boston Company to Mellon Bank in 1993, and Lehman Brothers was spun off in 1994.

16. 1999American Express

    Centurion Card launched

    American Express created the Centurion Card in 1999, an invitation-only metal card that became the top tier of its lineup. The company has never published its fee schedule, and the product functions mainly as a positioning device for the cards below it.

17. 2001American Express

    Kenneth Chenault becomes chief executive

    Kenneth Chenault became chief executive in January 2001, weeks before the September 11 attacks damaged the company's lower Manhattan operations and cut travel spending sharply.

18. 2001Amgen

    FDA approves Aranesp, the longer-acting EPO

    Aranesp (darbepoetin alfa), an erythropoietin analogue with modified glycosylation and a longer half-life, was approved in 2001. Less frequent dosing than Epogen improved convenience and gave Amgen a newer, higher-priced product to migrate patients toward.

19. 2002Amgen

    US$16 billion Immunex acquisition brings Enbrel in-house

    Amgen completed its acquisition of Immunex Corporation on July 16, 2002, the largest biotechnology deal to that point at about US$16 billion in stock and cash.

20. 2008American Express

    Conversion to a bank holding company

    On November 10, 2008 the Federal Reserve Board approved applications by American Express Company and American Express Travel Related Services to become bank holding companies, on conversion of American Express Centurion Bank from an industrial loan company int…

21. 2010Amgen

    Prolia and XGEVA create the bone health franchise

    The FDA approved Prolia (denosumab) for postmenopausal osteoporosis in June 2010 and XGEVA, the same molecule at a higher dose, for prevention of skeletal-related events in cancer patients in November 2010.

22. 2016American Express

    Costco co-brand ends

    Costco moved its United States co-branded card to Citigroup and Visa on June 20, 2016, ending a 16-year exclusive relationship after the two sides failed to agree terms, and stopped accepting American Express cards in its warehouses.

23. 2018American Express

    Stephen Squeri becomes chairman and chief executive

    Stephen Squeri succeeded Kenneth Chenault in February 2018 after more than three decades inside the company, including spells as chief information officer and group president of Global Corporate Services.

24. 2019Amgen

    US$13.4 billion purchase of Otezla from Celgene

    Amgen agreed in August 2019 to buy worldwide rights to Otezla (apremilast) from Celgene for US$13.4 billion in cash, or about US$11.2 billion net of the present value of US$2.2 billion of anticipated future cash tax benefits, and closed on November 21, 2019.

25. 2020American Express

    Pandemic hits travel and entertainment spending

    COVID-19 restrictions cut the travel and entertainment spending American Express depends on, and total revenues net of interest expense fell from 43.6 billion dollars in 2019 to 36.1 billion dollars in 2020, with net income down to 3.1 billion dollars.

26. 2020Amgen

    Amgen joins the Dow Jones Industrial Average

    Amgen replaced Pfizer in the Dow Jones Industrial Average on August 31, 2020, becoming one of the thirty components in the index. Inclusion recognized the scale Amgen had reached and added passive demand from Dow-tracking funds.

27. 2023Amgen

    US$27.8 billion Horizon Therapeutics acquisition closes

    Amgen completed the acquisition of Horizon Therapeutics plc on October 6, 2023 for US$116.50 per share in cash, an equity value of about US$27.8 billion, after settling FTC litigation with a behavioral consent decree.

28. 2024American Express

    Tock acquisition widens the dining platform

    American Express agreed in June 2024 to buy Tock, a reservation, table and event management platform, from Squarespace for 400 million dollars in cash, pairing it with Resy, which it had bought in 2019.

29. 2024Amgen

    Imdelltra becomes the first T-cell engager for small cell lung cancer

    The FDA granted accelerated approval to tarlatamab, sold as Imdelltra, on May 16, 2024 for extensive stage small cell lung cancer that has progressed on or after platinum-based chemotherapy.

30. 2025American Express

    Platinum refresh and record FY2025 results

    American Express unveiled refreshed United States Consumer and Business Platinum Cards on September 18, 2025, raising the annual fee from 695 dollars to 895 dollars and adding statement credits it values at over 3,500 dollars a year.

31. 2025Amgen

    VESALIUS-CV extends the Repatha case to primary prevention

    In November 2025 Amgen reported Phase 3 VESALIUS-CV results in more than 12,000 patients with atherosclerosis or diabetes but no prior heart attack or stroke.

32. 2026Amgen

    Medicare price setting reaches Enbrel and Otezla

    Enbrel's negotiated Medicare price under the Inflation Reduction Act took effect on January 1, 2026, after it was named in the first round of ten drugs selected for negotiation.

Acquisitions

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