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Companies Headquartered in San Diego

6 profiled companies are headquartered in San Diego. The largest by latest full-year revenue is Qualcomm Inc., at about $44.3 billion for 2025, followed by Realty Income Corporation at about $5.7 billion for 2025.

No two of these companies report the same industry; they cover 6 different ones.

Founding dates run from 1953 (WD-40 Company) to 2017 (ClickUp), so the list covers 64 years of companies that chose San Diego as their base.

Every figure above comes from the company profiles linked below, where each revenue number carries its fiscal year and source. Run-rates are never used as annual revenue, and revenue reported in other currencies is converted to US dollars at approximate 2025 average rates, so treat the comparison as an order of scale rather than an exact gap.

ClickUp
Productivity Software, Project Management, Collaboration, Enterprise SaaS, Workflow Automation & All-in-One Work Platforms
Est. 2017

ClickUp facts for 2026: $300M+ ARR, 20M+ users, $4B valuation, CEO Zeb Evans, Qatalog and Codegen deals, 22% layoffs, and Asana, Monday.com and Notion rivals.

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DexCom, Inc.
Medical Devices, Continuous Glucose Monitoring (CGM), Diabetes Care Technology
Est. 1999

Explore Dexcom (DXCM), the pioneer and gold standard in real-time Continuous Glucose Monitoring, its revenues, Stelo biosensor, and growth strategy.

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Qualcomm Inc.
Semiconductors & Wireless Technology
Est. 1985

Qualcomm profile: FY2025 revenue of $44.3B, Q3 FY2026 results, CEO Cristiano Amon, how QCT chips and QTL licensing make money, Apple modem exposure, and data

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Realty Income Corporation
Retail Net Lease Real Estate Investment Trust (REIT)
Est. 1969

Realty Income (NYSE: O) earned $5.75B revenue in FY2025 and $1.55B in Q2 2026. CEO Sumit Roy, 15,500+ net lease properties, monthly dividend, rivals.

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ResMed
Medical Devices & Digital Health
Est. 1989

Explore ResMed's cloud-connected sleep apnea devices, out-of-hospital SaaS platforms, audited financials, and global medtech market strategy.

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WD-40 Company
Maintenance products and specialty chemicals
Est. 1953

WD-40 Company profile: Rocket Chemical origins in 1953, fiscal 2025 net sales of $620.0M, Q3 fiscal 2026 results, CEO Steve Brass, brands and strategy.

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Content is for informational purposes only. Not financial advice. Data sourced from SEC filings, annual reports, and public records. See our full disclaimer and methodology.